Assay Detail
Functional
CHEMBL1045014
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Cytotoxicity against human SH-SY5Y cells assessed as cell viability after 48 hrs by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SH-SY5Y |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A novel potent nicotinamide phosphoribosyltransferase inhibitor synthesized via click chemistry.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.35 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL566757 | DAPORINAD | 2.0 | 1 | 8.77 |
| CHEMBL568305 | — | — | 1 | 8.42 |
| CHEMBL584300 | — | — | 1 | 7.84 |
| CHEMBL566109 | — | — | 1 | 7.43 |
| CHEMBL572770 | — | — | 1 | 7.43 |
| CHEMBL584510 | — | — | 1 | 7.25 |
| CHEMBL567439 | — | — | 1 | 7.14 |
| CHEMBL566110 | — | — | 1 | 7.11 |
| CHEMBL566342 | — | — | 1 | 7.09 |
| CHEMBL577804 | — | — | 1 | 7.03 |
| CHEMBL567650 | — | — | 1 | 7.01 |
| CHEMBL565709 | — | — | 1 | 6.92 |
| CHEMBL583215 | — | — | 1 | 6.80 |
| CHEMBL577060 | — | — | 1 | 6.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL566757 | DAPORINAD | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL568305 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL584300 | — | IC50 | = | 14.6 | nM | 7.84 |
| CHEMBL566109 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL572770 | — | IC50 | = | 37.4 | nM | 7.43 |
| CHEMBL584510 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL567439 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL566110 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL566342 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL577804 | — | IC50 | = | 92.9 | nM | 7.03 |
| CHEMBL567650 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL565709 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL583215 | — | IC50 | = | 157.0 | nM | 6.80 |
| CHEMBL577060 | — | IC50 | = | 205.0 | nM | 6.69 |