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Assay Detail

CHEMBL1045087

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ADMET
Antiproliferative activity against human SVCT-M12 cells after 72 hrs by trypan blue exclusion assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type SVCT-M12
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

ADMET (CHEMBL612558)
Type ADMET

Publication

Synthesis and evaluation of bioactive naphthoquinones from the Brazilian medicinal plant, Tabebuia avellanedae.
Yamashita M, Kaneko M, Tokuda H, Nishimura K, Kumeda Y, Iida A.
Bioorg Med Chem (2009) 17 : 6286 -6291
PubMed 19674905 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 7 5.27 6.02

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL105 MITOMYCIN 4.0 1 6.02
CHEMBL392591 1 5.47
CHEMBL611361 1 5.11
CHEMBL493650 1 4.93
CHEMBL611052 1 4.84
CHEMBL239211 1 -
CHEMBL392384 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL105 MITOMYCIN EC50 = 960.0 nM 6.02
CHEMBL392591 EC50 = 3360.0 nM 5.47
CHEMBL611361 EC50 = 7700.0 nM 5.11
CHEMBL493650 EC50 = 11700.0 nM 4.93
CHEMBL611052 EC50 = 14600.0 nM 4.84
CHEMBL239211 EC50 - -
CHEMBL392384 EC50 - -