Assay Detail

CHEMBL1045199

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Antimalarial activity against Plasmodium falciparum NF54

ChEMBL ↗

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Target

Plasmodium falciparum (CHEMBL364) ↗

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Primary target Plasmodium falciparum

CHEMBL364

Anchored from Assay target.

Protein identity Plasmodium falciparum

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Plasmodium falciparum
Confidence	1 — Organism
Curated By	Autocuration

Target

Plasmodium falciparum (CHEMBL364) ↗

Type	ORGANISM
Organism	Plasmodium falciparum

Publication

Synthesis and in vitro DMPK profiling of a 1,2-dioxolane-based library with activity against Plasmodium falciparum.

Martyn DC, Beletsky G, Cortese JF, Tyndall E, Liu H, Fitzgerald MM, O'Shea TJ, Liang B, Clardy J.
Bioorg Med Chem Lett (2009) 19 : 5657 -5660
PubMed 19699641 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	8.63	8.63

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL404431	OZ277	3.0	1	8.63

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL404431	OZ277	EC50	=	2.32	nM	8.63