Compound Detail
CHEMBL404431
OZ277 🧪 Phase III
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🧪 Phase III
CC(C)(N)CNC(=O)C[C@H]1CC[C@]2(CC1)OO[C@]1(O2)C2CC3CC(C2)CC1C3
Basic Information
| ChEMBL ID | CHEMBL404431 |
| Name | OZ277 |
| Phase | Phase III |
| Structure Type | MOL |
| InChI Key | VXYZBLXGCYNIHP-CAGINOIPSA-N |
2
Targets
11
Activities
3
Assay Types
8
PK Parameters
20
Publications
1
Known Names
1
Indications
Molecular Properties
392.5
MW (Da)
3.25
ALogP
5
HBA
2
HBD
82.8
PSA (Ų)
0.72
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Indications
Malaria, Falciparum
Activity Summary
IC50 6 meas. best 8.8
EC50 4 meas. best 8.63
Ki 1 meas. best 5.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Plasmodium falciparum CHEMBL364 | IC50 | 8.8 | 8.724 | 1.6 | 5 |
| Plasmodium falciparum CHEMBL364 | EC50 | 8.63 | 8.605 | 2.3 | 4 |
| Unchecked CHEMBL612545 | IC50 | 5.11 | 5.11 | 7700.0 | 1 |
| Unchecked CHEMBL612545 | Ki | 5.1 | 5.1 | 7900.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 2013.73 | ng.hr.mL-1 | Mus musculus |
| CL | 17.0 | mL.min-1.g-1 | Mus musculus |
| CL | 5.4 | mL.min-1.g-1 | Mus musculus |
| F | 13.0 | % | Rattus norvegicus |
| T1/2 | 0.93 | hr | Mus musculus |
| T1/2 | 1.0 | hr | Rattus norvegicus |
| T1/2 | 2.133 | hr | Mus musculus |
| T1/2 | 2.133 | hr | Mus musculus |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine