Assay Detail
Functional
CHEMBL4425206
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Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 after 24 hrs in presence of hypoxanthine
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antimalarial Chemotherapy: Natural Product Inspired Development of Preclinical and Clinical Candidates with Diverse Mechanisms of Action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.27 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL404431 | OZ277 | 3.0 | 1 | 8.74 |
| CHEMBL1828820 | ARTEFENOMEL | 2.0 | 1 | 8.47 |
| CHEMBL22590 | — | — | 1 | 7.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL404431 | OZ277 | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL1828820 | ARTEFENOMEL | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL22590 | — | IC50 | = | 25.0 | nM | 7.60 |