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Assay Detail

CHEMBL4040251

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human RBC after 48 hrs by YOYO-1 staining-based flow cytometry method
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Enantioselective Synthesis and in Vivo Evaluation of Regioisomeric Analogues of the Antimalarial Arterolane.
Blank BR, Gut J, Rosenthal PJ, Renslo AR.
J Med Chem (2017) 60 : 6400 -6407
PubMed 28692297 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 20 8.26 8.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1197732 1 8.89
CHEMBL1097091 1 8.72
CHEMBL404431 OZ277 3.0 1 8.60
CHEMBL1197388 1 8.59
CHEMBL4085726 1 8.54
CHEMBL4088900 1 8.52
CHEMBL1197363 1 8.44
CHEMBL4101217 1 8.41
CHEMBL4066652 1 8.39
CHEMBL4063113 1 8.36
CHEMBL1197434 1 8.35
CHEMBL4074482 1 8.31
CHEMBL4104318 1 8.27
CHEMBL4104539 1 8.23
CHEMBL4093470 1 8.17
CHEMBL571096 1 8.04
CHEMBL4062300 1 7.97
CHEMBL584940 1 7.68
CHEMBL4099964 1 7.50
CHEMBL584516 1 7.24

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1197732 EC50 = 1.3 nM 8.89
CHEMBL1097091 EC50 = 1.9 nM 8.72
CHEMBL404431 OZ277 EC50 = 2.5 nM 8.60
CHEMBL1197388 EC50 = 2.6 nM 8.59
CHEMBL4085726 EC50 = 2.9 nM 8.54
CHEMBL4088900 EC50 = 3.0 nM 8.52
CHEMBL1197363 EC50 = 3.6 nM 8.44
CHEMBL4101217 EC50 = 3.9 nM 8.41
CHEMBL4066652 EC50 = 4.1 nM 8.39
CHEMBL4063113 EC50 = 4.4 nM 8.36
CHEMBL1197434 EC50 = 4.5 nM 8.35
CHEMBL4074482 EC50 = 4.9 nM 8.31
CHEMBL4104318 EC50 = 5.4 nM 8.27
CHEMBL4104539 EC50 = 5.9 nM 8.23
CHEMBL4093470 EC50 = 6.8 nM 8.17
CHEMBL571096 EC50 = 9.2 nM 8.04
CHEMBL4062300 EC50 = 10.6 nM 7.97
CHEMBL584940 EC50 = 20.7 nM 7.68
CHEMBL4099964 EC50 = 31.4 nM 7.50
CHEMBL584516 EC50 = 57.0 nM 7.24