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Assay Detail

CHEMBL4836656

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 incubated for 72 hrs by spectrophotometry based parasite lactate dehydrogenase assay
21
Total Activities
21
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Enantioselective Synthesis and Profiling of Potent, Nonlinear Analogues of Antimalarial Tetraoxanes E209 and N205.
Woodley CM, Nixon GL, Basilico N, Parapini S, Hong WD, Ward SA, Biagini GA, Leung SC, Taramelli D, Onuma K, Hasebe T, O'Neill PM.
ACS Med Chem Lett (2021) 12 : 1077 -1085
PubMed 34267877 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 7.85 8.99
EC50 3 8.58 8.74

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL307261 ARTENIMOL 3.0 1 8.99
CHEMBL4865478 1 8.74
CHEMBL404431 OZ277 3.0 1 8.60
CHEMBL4101217 1 8.41
CHEMBL4288940 1 8.07
CHEMBL4127539 1 8.06
CHEMBL4846611 1 8.00
CHEMBL4870775 1 7.99
CHEMBL4846750 1 7.95
CHEMBL4860386 1 7.95
CHEMBL4126164 1 7.93
CHEMBL4865116 1 7.89
CHEMBL4864612 1 7.84
CHEMBL4876270 1 7.83
CHEMBL4878749 1 7.82
CHEMBL4864373 1 7.80
CHEMBL4875047 1 7.80
CHEMBL4859184 1 7.75
CHEMBL4867438 1 7.72
CHEMBL4850666 1 7.65
CHEMBL76 CHLOROQUINE 4.0 1 6.33

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL307261 ARTENIMOL IC50 = 1.02 nM 8.99
CHEMBL4865478 EC50 = 1.8 nM 8.74
CHEMBL404431 OZ277 EC50 = 2.5 nM 8.60
CHEMBL4101217 EC50 = 3.9 nM 8.41
CHEMBL4288940 IC50 = 8.49 nM 8.07
CHEMBL4127539 IC50 = 8.65 nM 8.06
CHEMBL4846611 IC50 = 10.12 nM 8.00
CHEMBL4870775 IC50 = 10.28 nM 7.99
CHEMBL4846750 IC50 = 11.25 nM 7.95
CHEMBL4860386 IC50 = 11.22 nM 7.95
CHEMBL4126164 IC50 = 11.74 nM 7.93
CHEMBL4865116 IC50 = 12.8 nM 7.89
CHEMBL4864612 IC50 = 14.44 nM 7.84
CHEMBL4876270 IC50 = 14.88 nM 7.83
CHEMBL4878749 IC50 = 15.2 nM 7.82
CHEMBL4864373 IC50 = 15.82 nM 7.80
CHEMBL4875047 IC50 = 15.98 nM 7.80
CHEMBL4859184 IC50 = 17.68 nM 7.75
CHEMBL4867438 IC50 = 19.2 nM 7.72
CHEMBL4850666 IC50 = 22.46 nM 7.65
CHEMBL76 CHLOROQUINE IC50 = 462.02 nM 6.33