Compound Detail
CHEMBL4860386
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Basic Information
| ChEMBL ID | CHEMBL4860386 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SGNRYIMMYSHVSW-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
455.6
MW (Da)
4.94
ALogP
6
HBA
0
HBD
49.4
PSA (Ų)
0.60
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.95
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Plasmodium falciparum CHEMBL364 | IC50 | 7.95 | 7.88 | 11.2 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Plasmodium falciparum | IC50 | = | 11.22 | nM | 7.95 | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 i... | 34267877 |
| Plasmodium falciparum | IC50 | = | 15.43 | nM | 7.81 | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 ... | 34267877 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34267877 | 10.1021/acsmedchemlett.1c00031 | Plasmodium falciparum | 2 |
Data from ChEMBL 36 via Core Engine