Assay Detail
Functional
CHEMBL1045234
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Antiviral activity against HIV1 3B infected human HOS cells expressing human CXCR4 and CD4 assessed as inhibition of viral infection by luciferase reporter gene assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | HOS |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Imidazopyridine-5,6,7,8-tetrahydro-8-quinolinamine derivatives with potent activity against HIV-1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.92 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL570532 | — | — | 1 | 9.22 |
| CHEMBL583255 | — | — | 1 | 8.70 |
| CHEMBL570522 | — | — | 1 | 8.70 |
| CHEMBL570791 | — | — | 1 | 8.52 |
| CHEMBL570984 | — | — | 1 | 8.52 |
| CHEMBL585016 | — | — | 1 | 8.52 |
| CHEMBL585722 | — | — | 1 | 8.40 |
| CHEMBL583252 | — | — | 1 | 8.40 |
| CHEMBL571652 | — | — | 1 | 8.40 |
| CHEMBL584751 | — | — | 1 | 8.40 |
| CHEMBL571202 | — | — | 1 | 8.40 |
| CHEMBL571458 | — | — | 1 | 8.30 |
| CHEMBL570301 | — | — | 1 | 8.10 |
| CHEMBL571651 | — | — | 1 | 7.77 |
| CHEMBL571438 | — | — | 1 | 7.64 |
| CHEMBL570967 | — | — | 1 | 7.55 |
| CHEMBL570757 | — | — | 1 | 7.52 |
| CHEMBL569613 | — | — | 1 | 7.37 |
| CHEMBL570968 | — | — | 1 | 7.31 |
| CHEMBL583458 | — | — | 1 | 7.08 |
| CHEMBL585350 | — | — | 1 | 6.90 |
| CHEMBL570300 | — | — | 1 | 6.19 |
| CHEMBL570787 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL570532 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL583255 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL570522 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL570791 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL570984 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL585016 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL585722 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL583252 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL571652 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL584751 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL571202 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL571458 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL570301 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL571651 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL571438 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL570967 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL570757 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL569613 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL570968 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL583458 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL585350 | — | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL570300 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL570787 | — | IC50 | = | 690.0 | nM | 6.16 |