Assay Detail
Binding
CHEMBL1045247
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Inhibition of human somatic ACE C-terminal domain
15
Total Activities
15
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Phosphinic tripeptides as dual angiotensin-converting enzyme C-domain and endothelin-converting enzyme-1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 8.40 | 9.40 |
| IC50 | 1 | 8.60 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL570718 | — | — | 1 | 9.40 |
| CHEMBL570732 | — | — | 1 | 9.39 |
| CHEMBL570953 | — | — | 1 | 9.19 |
| CHEMBL577753 | — | — | 1 | 8.85 |
| CHEMBL43370 | — | — | 1 | 8.60 |
| CHEMBL571716 | — | — | 1 | 8.52 |
| CHEMBL577754 | — | — | 1 | 8.44 |
| CHEMBL567628 | — | — | 1 | 8.42 |
| CHEMBL570811 | — | — | 1 | 8.30 |
| CHEMBL289556 | OMAPATRILAT | 2.0 | 1 | 8.22 |
| CHEMBL570740 | — | — | 1 | 7.92 |
| CHEMBL570842 | — | — | 1 | 7.89 |
| CHEMBL570843 | — | — | 1 | 7.80 |
| CHEMBL570704 | — | — | 1 | 7.70 |
| CHEMBL570722 | — | — | 1 | 7.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL570718 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL570732 | — | Ki | = | 0.41 | nM | 9.39 |
| CHEMBL570953 | — | Ki | = | 0.65 | nM | 9.19 |
| CHEMBL577753 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL43370 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL571716 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL577754 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL567628 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL570811 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL289556 | OMAPATRILAT | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL570740 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL570842 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL570843 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL570704 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL570722 | — | Ki | = | 25.0 | nM | 7.60 |