Assay Detail
Binding
CHEMBL1045249
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Inhibition of human somatic ECE1
17
Total Activities
17
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Phosphinic tripeptides as dual angiotensin-converting enzyme C-domain and endothelin-converting enzyme-1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 7.33 | 8.92 |
| IC50 | 3 | 6.89 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL571153 | — | — | 1 | 8.92 |
| CHEMBL567628 | — | — | 1 | 8.11 |
| CHEMBL577754 | — | — | 1 | 8.10 |
| CHEMBL570953 | — | — | 1 | 7.85 |
| CHEMBL570843 | — | — | 1 | 7.85 |
| CHEMBL146936 | — | — | 1 | 7.66 |
| CHEMBL577753 | — | — | 1 | 7.58 |
| CHEMBL43370 | — | — | 1 | 7.10 |
| CHEMBL570718 | — | — | 1 | 6.62 |
| CHEMBL570732 | — | — | 1 | 6.56 |
| CHEMBL570842 | — | — | 1 | 6.04 |
| CHEMBL479579 | PHOSPHORAMIDON | — | 1 | 5.92 |
| CHEMBL570811 | — | — | 1 | 5.68 |
| CHEMBL570722 | — | — | 1 | - |
| CHEMBL570740 | — | — | 1 | - |
| CHEMBL570704 | — | — | 1 | - |
| CHEMBL571716 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL571153 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL567628 | — | Ki | = | 7.7 | nM | 8.11 |
| CHEMBL577754 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL570953 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL570843 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL146936 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL577753 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL43370 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL570718 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL570732 | — | Ki | = | 275.0 | nM | 6.56 |
| CHEMBL570842 | — | Ki | = | 910.0 | nM | 6.04 |
| CHEMBL479579 | PHOSPHORAMIDON | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL570811 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL570722 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL570740 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL570704 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL571716 | — | Ki | > | 50000.0 | nM | - |