Assay Detail
Functional
CHEMBL1045263
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells coexpressing phospholipase C-activating Gq protein assessed as [3H]inositol phosphate production
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | 1321-N1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Human P2Y(14) receptor agonists: truncation of the hexose moiety of uridine-5'-diphosphoglucose and its replacement with alkyl and aryl groups.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 5.89 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL567321 | — | — | 1 | 7.38 |
| CHEMBL1204010 | — | — | 1 | 7.16 |
| CHEMBL566925 | — | — | 1 | 6.90 |
| CHEMBL507060 | — | — | 1 | 6.47 |
| CHEMBL216011 | — | — | 1 | 6.35 |
| CHEMBL130266 | URIDINE_DIPHOSPHATE | — | 1 | 6.28 |
| CHEMBL612064 | — | — | 1 | 5.82 |
| CHEMBL375951 | URIDINE DIPHOSPHATE GLUCOSE | — | 1 | 5.80 |
| CHEMBL611791 | — | — | 1 | 5.70 |
| CHEMBL1162556 | — | — | 1 | 5.69 |
| CHEMBL384992 | — | — | 1 | 5.63 |
| CHEMBL612119 | — | — | 1 | 5.56 |
| CHEMBL1162561 | — | — | 1 | 5.13 |
| CHEMBL1162559 | — | — | 1 | 5.13 |
| CHEMBL612063 | — | — | 1 | 5.10 |
| CHEMBL1162553 | — | — | 1 | 5.04 |
| CHEMBL608851 | — | — | 1 | 4.98 |
| CHEMBL1162552 | — | — | 1 | - |
| CHEMBL488133 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL567321 | — | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL1204010 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL566925 | — | EC50 | = | 127.0 | nM | 6.90 |
| CHEMBL507060 | — | EC50 | = | 339.0 | nM | 6.47 |
| CHEMBL216011 | — | EC50 | = | 447.0 | nM | 6.35 |
| CHEMBL130266 | URIDINE_DIPHOSPHATE | EC50 | = | 530.0 | nM | 6.28 |
| CHEMBL612064 | — | EC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL375951 | URIDINE DIPHOSPHATE GLUCOSE | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL611791 | — | EC50 | = | 1990.0 | nM | 5.70 |
| CHEMBL1162556 | — | EC50 | = | 2040.0 | nM | 5.69 |
| CHEMBL384992 | — | EC50 | = | 2360.0 | nM | 5.63 |
| CHEMBL612119 | — | EC50 | = | 2760.0 | nM | 5.56 |
| CHEMBL1162561 | — | EC50 | = | 7370.0 | nM | 5.13 |
| CHEMBL1162559 | — | EC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL612063 | — | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL1162553 | — | EC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL608851 | — | EC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL1162552 | — | EC50 | = | 108000.0 | nM | - |
| CHEMBL488133 | — | EC50 | - | — | - |