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Compound Detail

CHEMBL375951

URIDINE DIPHOSPHATE GLUCOSE
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O=c1ccn([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@@H](O)[C@H]2O)c(=O)[nH]1

Basic Information

ChEMBL ID CHEMBL375951
Name URIDINE DIPHOSPHATE GLUCOSE
Phase Preclinical
Structure Type MOL
InChI Key HSCJRCZFDFQWRP-JZMIEXBBSA-N
3
Targets
7
Activities
1
Assay Types
0
PK Parameters
9
Publications
0
Known Names

Molecular Properties

566.3
MW (Da)
-4.79
ALogP
16
HBA
9
HBD
297.0
PSA (Ų)
0.13
QED
3
Ro5 Violations
9
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C15H24N2O17P2
MW 566.30
Aromatic Rings 1
Heavy Atoms 36
NP-Likeness 1.49

Activity Summary

EC50 7 meas. best 6.58

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
P2Y purinoceptor 14
CHEMBL4518
EC50 6.58 6.4725 261.0 4
P2Y purinoceptor 6
CHEMBL4714
EC50 5.8 5.8 1600.0 1
P2Y purinoceptor 2
CHEMBL4398
EC50 5.0 5.0 10000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
18443110 10.1128/aac.00262-08 Unchecked 30
19502066 10.1016/j.bmc.2009.05.024 P2Y purinoceptor 2 2
17407275 10.1021/jm061222w P2Y purinoceptor 14 1
17088057 10.1016/j.bmcl.2006.10.081 P2Y purinoceptor 14 1
19902968 10.1021/jm901432g P2Y purinoceptor 6 1
19902968 10.1021/jm901432g P2Y purinoceptor 14 1
19502066 10.1016/j.bmc.2009.05.024 P2Y purinoceptor 14 1
24900835 10.1021/ml400399f Uracil nucleotide/cysteinyl leukotriene receptor 1
25868749 10.1016/j.bmc.2015.03.042 P2Y purinoceptor 14 1

Data from ChEMBL 36 via Core Engine