Assay Detail
Functional
CHEMBL902452
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human P2Y14 receptor expressed in COS7 cells assessed as stimulation of PLC
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | COS-7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Molecular dynamics simulation of the P2Y14 receptor. Ligand docking and identification of a putative binding site of the distal hexose moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.10 | 6.45 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL375951 | URIDINE DIPHOSPHATE GLUCOSE | — | 1 | 6.45 |
| CHEMBL1162071 | — | — | 1 | 6.43 |
| CHEMBL1743884 | UDP-GALACTOSE | — | 1 | 6.17 |
| CHEMBL1162072 | — | — | 1 | 5.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL375951 | URIDINE DIPHOSPHATE GLUCOSE | EC50 | = | 354.0 | nM | 6.45 |
| CHEMBL1162071 | — | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL1743884 | UDP-GALACTOSE | EC50 | = | 671.0 | nM | 6.17 |
| CHEMBL1162072 | — | EC50 | = | 4380.0 | nM | 5.36 |