Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL917907

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Agonist activity at human P2Y14 expressed in COS7 cells assessed as stimulation of PLC-mediated [3H]inositol hydrolysis
12
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type COS-7
Confidence 9 — Direct single protein target
Curated By Expert

Target

P2Y purinoceptor 14 (CHEMBL4518)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Structure-activity relationship of uridine 5'-diphosphoglucose analogues as agonists of the human P2Y14 receptor.
Ko H, Fricks I, Ivanov AA, Harden TK, Jacobson KA.
J Med Chem (2007) 50 : 2030 -2039
PubMed 17407275 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 12 6.23 7.31

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL228111 1 7.31
CHEMBL375951 URIDINE DIPHOSPHATE GLUCOSE 1 6.46
CHEMBL374384 1 6.46
CHEMBL228057 1 6.43
CHEMBL387520 1 6.38
CHEMBL439009 1 6.17
CHEMBL1162072 2 6.09
CHEMBL226713 1 6.06
CHEMBL227711 1 6.04
CHEMBL390160 1 5.73
CHEMBL439378 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL228111 EC50 = 49.0 nM 7.31
CHEMBL375951 URIDINE DIPHOSPHATE GLUCOSE EC50 = 350.0 nM 6.46
CHEMBL374384 EC50 = 350.0 nM 6.46
CHEMBL228057 EC50 = 370.0 nM 6.43
CHEMBL387520 EC50 = 420.0 nM 6.38
CHEMBL439009 EC50 = 670.0 nM 6.17
CHEMBL1162072 EC50 = 810.0 nM 6.09
CHEMBL226713 EC50 = 880.0 nM 6.06
CHEMBL227711 EC50 = 910.0 nM 6.04
CHEMBL390160 EC50 = 1880.0 nM 5.73
CHEMBL1162072 EC50 = 4380.0 nM 5.36
CHEMBL439378 EC50 > 10000.0 nM -