Assay Detail
Functional
CHEMBL1045264
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human P2Y14 receptor expressed in HEK293 cells coexpressing phospholipase C-activating Gi protein cells assessed as inhibition of forskolin induced [3H]cAMP production
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Human P2Y(14) receptor agonists: truncation of the hexose moiety of uridine-5'-diphosphoglucose and its replacement with alkyl and aryl groups.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 28 | 6.69 | 9.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL611791 | — | — | 1 | 9.04 |
| CHEMBL216011 | — | — | 1 | 8.72 |
| CHEMBL374384 | — | — | 1 | 7.96 |
| CHEMBL611792 | — | — | 1 | 7.96 |
| CHEMBL507060 | — | — | 1 | 7.96 |
| CHEMBL1162556 | — | — | 1 | 7.50 |
| CHEMBL1162563 | — | — | 1 | 7.41 |
| CHEMBL1162553 | — | — | 1 | 7.40 |
| CHEMBL1162557 | — | — | 1 | 7.25 |
| CHEMBL488133 | — | — | 1 | 7.20 |
| CHEMBL566925 | — | — | 1 | 6.85 |
| CHEMBL130266 | URIDINE_DIPHOSPHATE | — | 1 | 6.80 |
| CHEMBL612065 | — | — | 1 | 6.78 |
| CHEMBL1162552 | — | — | 1 | 6.60 |
| CHEMBL384992 | — | — | 1 | 6.50 |
| CHEMBL375951 | URIDINE DIPHOSPHATE GLUCOSE | — | 1 | 6.40 |
| CHEMBL612064 | — | — | 1 | 6.32 |
| CHEMBL1162559 | — | — | 1 | 6.12 |
| CHEMBL612119 | — | — | 1 | 5.83 |
| CHEMBL1162560 | — | — | 1 | 5.80 |
| CHEMBL1162561 | — | — | 1 | 5.75 |
| CHEMBL1162562 | — | — | 1 | 5.72 |
| CHEMBL1162554 | — | — | 1 | 5.56 |
| CHEMBL1204010 | — | — | 1 | 5.48 |
| CHEMBL612063 | — | — | 1 | 5.34 |
| CHEMBL1162558 | — | — | 1 | 5.29 |
| CHEMBL1162555 | — | — | 1 | 5.13 |
| CHEMBL608851 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL611791 | — | EC50 | = | 0.92 | nM | 9.04 |
| CHEMBL216011 | — | EC50 | = | 1.92 | nM | 8.72 |
| CHEMBL374384 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL611792 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL507060 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1162556 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL1162563 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL1162553 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1162557 | — | EC50 | = | 56.0 | nM | 7.25 |
| CHEMBL488133 | — | EC50 | = | 63.0 | nM | 7.20 |
| CHEMBL566925 | — | EC50 | = | 142.0 | nM | 6.85 |
| CHEMBL130266 | URIDINE_DIPHOSPHATE | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL612065 | — | EC50 | = | 167.0 | nM | 6.78 |
| CHEMBL1162552 | — | EC50 | = | 252.0 | nM | 6.60 |
| CHEMBL384992 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL375951 | URIDINE DIPHOSPHATE GLUCOSE | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL612064 | — | EC50 | = | 480.0 | nM | 6.32 |
| CHEMBL1162559 | — | EC50 | = | 768.0 | nM | 6.12 |
| CHEMBL612119 | — | EC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL1162560 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1162561 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL1162562 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL1162554 | — | EC50 | = | 2730.0 | nM | 5.56 |
| CHEMBL1204010 | — | EC50 | = | 3320.0 | nM | 5.48 |
| CHEMBL612063 | — | EC50 | = | 4580.0 | nM | 5.34 |
| CHEMBL1162558 | — | EC50 | = | 5160.0 | nM | 5.29 |
| CHEMBL1162555 | — | EC50 | = | 7460.0 | nM | 5.13 |
| CHEMBL608851 | — | EC50 | - | — | - |