Assay Detail
Binding
CHEMBL1045455
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Inhibition of recombinant CK1delta kinase domain by Cherenkov counting
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
3,4-Diaryl-isoxazoles and -imidazoles as potent dual inhibitors of p38alpha mitogen activated protein kinase and casein kinase 1delta.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.85 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL569114 | — | — | 1 | 8.40 |
| CHEMBL572006 | — | — | 1 | 8.30 |
| CHEMBL571142 | — | — | 1 | 7.48 |
| CHEMBL569151 | — | — | 1 | 6.96 |
| CHEMBL585533 | — | — | 1 | 6.16 |
| CHEMBL566058 | — | — | 1 | 6.09 |
| CHEMBL571357 | — | — | 1 | 5.80 |
| CHEMBL569552 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL569114 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL572006 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL571142 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL569151 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL585533 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL566058 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL571357 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL569552 | — | IC50 | = | 2500.0 | nM | 5.60 |