Assay Detail
Functional
CHEMBL1045678
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition of proapoptotic stimuli-resistant human OE21 cells after 72 hrs by MTT assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | OE21 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Lycorine, the main phenanthridine Amaryllidaceae alkaloid, exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli: an investigation of structure-activity relationship and mechanistic insight.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.15 | 5.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL574915 | LYCORINE HYDROCHLORIDE | — | 1 | 5.34 |
| CHEMBL400092 | LYCORINE | — | 1 | 5.29 |
| CHEMBL575533 | AMARBELLISINE | — | 1 | 5.17 |
| CHEMBL586091 | PSEUDOLYCORINE | — | 1 | 5.11 |
| CHEMBL575109 | — | — | 1 | 5.07 |
| CHEMBL481250 | ANHYDROLYCORINE | — | 1 | 5.06 |
| CHEMBL575771 | — | — | 1 | 5.02 |
| CHEMBL251077 | — | — | 1 | - |
| CHEMBL465295 | — | — | 1 | - |
| CHEMBL583716 | — | — | 1 | - |
| CHEMBL516707 | — | — | 1 | - |
| CHEMBL572497 | — | — | 1 | - |
| CHEMBL583061 | — | — | 1 | - |
| CHEMBL573894 | — | — | 1 | - |
| CHEMBL568254 | — | — | 1 | - |
| CHEMBL566739 | — | — | 1 | - |
| CHEMBL575315 | — | — | 1 | - |
| CHEMBL574900 | — | — | 1 | - |
| CHEMBL575124 | LYCORENE | — | 1 | - |
| CHEMBL575125 | CARANINE | — | 1 | - |
| CHEMBL584172 | NORPLUVINE | — | 1 | - |
| CHEMBL479291 | UNGEREMINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL574915 | LYCORINE HYDROCHLORIDE | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL400092 | LYCORINE | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL575533 | AMARBELLISINE | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL586091 | PSEUDOLYCORINE | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL575109 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL481250 | ANHYDROLYCORINE | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL575771 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL251077 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL465295 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL583716 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL516707 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL572497 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL583061 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL573894 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL568254 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL566739 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL575315 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL574900 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL575124 | LYCORENE | IC50 | > | 10000.0 | nM | - |
| CHEMBL575125 | CARANINE | IC50 | > | 10000.0 | nM | - |
| CHEMBL584172 | NORPLUVINE | IC50 | > | 10000.0 | nM | - |
| CHEMBL479291 | UNGEREMINE | IC50 | > | 10000.0 | nM | - |