Assay Detail
Functional
CHEMBL1045774
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Cytotoxicity against human HCT116 cells assessed as reduction in cell number after 96 hrs by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of coumarin-based inhibitors of NAD(P)H: quinone oxidoreductase-1 (NQO1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 4.41 | 4.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1466 | DICUMAROL | 4.0 | 1 | 4.72 |
| CHEMBL570570 | — | — | 1 | 4.58 |
| CHEMBL571058 | — | — | 1 | 4.46 |
| CHEMBL569640 | — | — | 1 | 4.46 |
| CHEMBL569641 | — | — | 1 | 4.41 |
| CHEMBL576081 | — | — | 1 | 4.40 |
| CHEMBL583323 | — | — | 1 | 4.32 |
| CHEMBL569169 | — | — | 1 | 4.25 |
| CHEMBL571496 | — | — | 1 | 4.10 |
| CHEMBL569627 | — | — | 1 | - |
| CHEMBL570332 | — | — | 1 | - |
| CHEMBL570349 | — | — | 1 | - |
| CHEMBL573693 | — | — | 1 | - |
| CHEMBL571059 | — | — | 1 | - |
| CHEMBL571272 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1466 | DICUMAROL | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL570570 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL571058 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL569640 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL569641 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL576081 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL583323 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL569169 | — | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL571496 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL569627 | — | IC50 | = | 187000.0 | nM | - |
| CHEMBL570332 | — | IC50 | > | 400000.0 | nM | - |
| CHEMBL570349 | — | IC50 | = | 180000.0 | nM | - |
| CHEMBL573693 | — | IC50 | = | 178000.0 | nM | - |
| CHEMBL571059 | — | IC50 | = | 102000.0 | nM | - |
| CHEMBL571272 | — | IC50 | = | 176000.0 | nM | - |