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Assay Detail

CHEMBL1045779

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against rat L6 cells
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Rattus norvegicus
Cell Type L6
Confidence 1 — Organism
Curated By Autocuration

Target

L6 (CHEMBL614793)
Type CELL-LINE
Organism Rattus norvegicus

Publication

Alkyl and dialkylaminoethyl derivatives of 5-amino-2-azabicyclo[3.2.2]nonanes and their antiplasmodial and antitrypanosomal activities.
Faist J, Seebacher W, Kaiser M, Brun R, Saf R, Weis R.
Eur J Med Chem (2010) 45 : 179 -185
PubMed 19879671 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 4.94 5.47

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL583882 1 5.47
CHEMBL570563 1 5.43
CHEMBL566748 1 5.38
CHEMBL583466 1 5.34
CHEMBL565880 1 5.33
CHEMBL570359 1 5.13
CHEMBL565671 1 5.13
CHEMBL585547 1 5.10
CHEMBL216966 1 5.09
CHEMBL576469 1 5.08
CHEMBL387011 1 5.06
CHEMBL376631 1 5.00
CHEMBL584100 1 4.24
CHEMBL571934 1 4.09
CHEMBL414705 1 4.05
CHEMBL578399 1 4.04
CHEMBL585162 1 -
CHEMBL269671 ARTEMISININ 3.0 1 -
CHEMBL76 CHLOROQUINE 4.0 1 -
CHEMBL569175 1 -
CHEMBL219073 1 -
CHEMBL584305 1 -
CHEMBL571933 1 -
CHEMBL375182 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL583882 IC50 = 3400.0 nM 5.47
CHEMBL570563 IC50 = 3690.0 nM 5.43
CHEMBL566748 IC50 = 4220.0 nM 5.38
CHEMBL583466 IC50 = 4600.0 nM 5.34
CHEMBL565880 IC50 = 4650.0 nM 5.33
CHEMBL570359 IC50 = 7340.0 nM 5.13
CHEMBL565671 IC50 = 7330.0 nM 5.13
CHEMBL585547 IC50 = 7890.0 nM 5.10
CHEMBL216966 IC50 = 8100.0 nM 5.09
CHEMBL576469 IC50 = 8400.0 nM 5.08
CHEMBL387011 IC50 = 8740.0 nM 5.06
CHEMBL376631 IC50 = 10060.0 nM 5.00
CHEMBL584100 IC50 = 58220.0 nM 4.24
CHEMBL571934 IC50 = 80410.0 nM 4.09
CHEMBL414705 IC50 = 89740.0 nM 4.05
CHEMBL578399 IC50 = 92080.0 nM 4.04
CHEMBL585162 IC50 = 155700.0 nM -
CHEMBL269671 ARTEMISININ IC50 = 450500.0 nM -
CHEMBL76 CHLOROQUINE IC50 = 188500.0 nM -
CHEMBL569175 IC50 - -
CHEMBL219073 IC50 = 108800.0 nM -
CHEMBL584305 IC50 - -
CHEMBL571933 IC50 = 109000.0 nM -
CHEMBL375182 IC50 = 120400.0 nM -