Assay Detail
Functional
CHEMBL1045872
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Cytotoxicity against human SH-SY5Y cells assessed as reduction of total cellular NAD(P) level
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SH-SY5Y |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A novel potent nicotinamide phosphoribosyltransferase inhibitor synthesized via click chemistry.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.04 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL566757 | DAPORINAD | 2.0 | 1 | 9.30 |
| CHEMBL568305 | — | — | 1 | 8.52 |
| CHEMBL577804 | — | — | 1 | 8.24 |
| CHEMBL572770 | — | — | 1 | 7.77 |
| CHEMBL567650 | — | — | 1 | 7.31 |
| CHEMBL584300 | — | — | 1 | 7.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL566757 | DAPORINAD | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL568305 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL577804 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL572770 | — | IC50 | = | 17.1 | nM | 7.77 |
| CHEMBL567650 | — | IC50 | = | 49.2 | nM | 7.31 |
| CHEMBL584300 | — | IC50 | = | 84.4 | nM | 7.07 |