Assay Detail
Functional
CHEMBL1045938
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Agonist activity at mu opioid receptor in guinea pig ileum assessed as effect on muscle contraction
8
Total Activities
8
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Agonist vs antagonist behavior of delta opioid peptides containing novel phenylalanine analogues in place of Tyr(1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.11 | 6.11 |
| IC40 | 2 | - | - |
| IC35 | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL555206 | — | — | 1 | 6.11 |
| CHEMBL572542 | — | — | 1 | - |
| CHEMBL583285 | — | — | 1 | - |
| CHEMBL583486 | — | — | 1 | - |
| CHEMBL583485 | — | — | 1 | - |
| CHEMBL191751 | — | — | 1 | - |
| CHEMBL485576 | — | — | 1 | - |
| CHEMBL571492 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL555206 | — | IC50 | = | 769.0 | nM | 6.11 |
| CHEMBL572542 | — | IC40 | = | 223.0 | nM | - |
| CHEMBL583285 | — | IC35 | = | 458.0 | nM | - |
| CHEMBL583486 | — | IC35 | = | 721.0 | nM | - |
| CHEMBL583485 | — | IC40 | = | 1460.0 | nM | - |
| CHEMBL191751 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL485576 | — | IC50 | - | — | - | |
| CHEMBL571492 | — | IC50 | - | — | - |