Assay Detail
Functional
CHEMBL1046026
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antibacterial activity against Mycobacterium intracellular by alamar blue assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mycobacterium intracellulare |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Mycobacterium intracellulare (CHEMBL612640) ↗| Type | ORGANISM |
| Organism | Mycobacterium intracellulare |
Publication
Structure-activity relationship studies of manzamine A: amidation of positions 6 and 8 of the beta-carboline moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.80 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL595533 | 8-N-HEXAMIDOMANZAMINE A | — | 1 | 7.52 |
| CHEMBL612054 | — | — | 1 | 6.75 |
| CHEMBL608123 | 8-N-OCTAMIDOMANZAMINE A | — | 1 | 6.29 |
| CHEMBL608121 | 8-PIVALAMIDOMANZAMINE A | — | 1 | 6.27 |
| CHEMBL403233 | MANZAMINE A | — | 1 | 6.19 |
| CHEMBL608119 | 8-N-PENTAMIDOMANZAMINE A | — | 1 | 6.16 |
| CHEMBL595418 | 8-N-BUTAMIDOMANZAMINE A | — | 1 | 6.06 |
| CHEMBL607833 | 8-ISOBUTAMIDOMANZAMINE A | — | 1 | 5.99 |
| CHEMBL8 | CIPROFLOXACIN | 4.0 | 1 | 5.98 |
| CHEMBL595621 | 6-CYCLOHEXAMIDOMANZAMINE A | — | 1 | 5.90 |
| CHEMBL595275 | — | — | 1 | 5.87 |
| CHEMBL608124 | — | — | 1 | 5.82 |
| CHEMBL595391 | 8-N-PROPAMIDOMANZAMINE A | — | 1 | 5.82 |
| CHEMBL608120 | 6-PIVALAMIDOANZAMINE A | — | 1 | 5.81 |
| CHEMBL595522 | 8-ACETAMIDOMANZAMINE A | — | 1 | 5.78 |
| CHEMBL595532 | 6-N-PENTAMIDOMANZAMINE A | — | 1 | 5.63 |
| CHEMBL607832 | 6-ISOBUTAMIDOMANZAMINE A | — | 1 | 5.50 |
| CHEMBL595461 | 6-N-BUTAMIDOMANZAMINE A | — | 1 | 5.33 |
| CHEMBL595515 | 6-N-PROPAMIDOMANZAMINE A | — | 1 | 5.25 |
| CHEMBL595531 | 6-ACETAMIDOMANZAMINE A | — | 1 | 5.00 |
| CHEMBL595762 | 8-CYCLOHEXAMIDOMANZAMINE A | — | 1 | 4.95 |
| CHEMBL595435 | 6-N-HEXAMIDOMANZAMINE A | — | 1 | 4.82 |
| CHEMBL608122 | 6-N-OCTAMIDOMANZAMINE A | — | 1 | 4.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL595533 | 8-N-HEXAMIDOMANZAMINE A | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL612054 | — | IC50 | = | 177.0 | nM | 6.75 |
| CHEMBL608123 | 8-N-OCTAMIDOMANZAMINE A | IC50 | = | 508.0 | nM | 6.29 |
| CHEMBL608121 | 8-PIVALAMIDOMANZAMINE A | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL403233 | MANZAMINE A | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL608119 | 8-N-PENTAMIDOMANZAMINE A | IC50 | = | 695.0 | nM | 6.16 |
| CHEMBL595418 | 8-N-BUTAMIDOMANZAMINE A | IC50 | = | 868.0 | nM | 6.06 |
| CHEMBL607833 | 8-ISOBUTAMIDOMANZAMINE A | IC50 | = | 1026.0 | nM | 5.99 |
| CHEMBL8 | CIPROFLOXACIN | IC50 | = | 1056.0 | nM | 5.98 |
| CHEMBL595621 | 6-CYCLOHEXAMIDOMANZAMINE A | IC50 | = | 1262.0 | nM | 5.90 |
| CHEMBL595275 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL608124 | — | IC50 | = | 1511.0 | nM | 5.82 |
| CHEMBL595391 | 8-N-PROPAMIDOMANZAMINE A | IC50 | = | 1517.0 | nM | 5.82 |
| CHEMBL608120 | 6-PIVALAMIDOANZAMINE A | IC50 | = | 1544.0 | nM | 5.81 |
| CHEMBL595522 | 8-ACETAMIDOMANZAMINE A | IC50 | = | 1651.0 | nM | 5.78 |
| CHEMBL595532 | 6-N-PENTAMIDOMANZAMINE A | IC50 | = | 2316.0 | nM | 5.63 |
| CHEMBL607832 | 6-ISOBUTAMIDOMANZAMINE A | IC50 | = | 3157.0 | nM | 5.50 |
| CHEMBL595461 | 6-N-BUTAMIDOMANZAMINE A | IC50 | = | 4736.0 | nM | 5.33 |
| CHEMBL595515 | 6-N-PROPAMIDOMANZAMINE A | IC50 | = | 5650.0 | nM | 5.25 |
| CHEMBL595531 | 6-ACETAMIDOMANZAMINE A | IC50 | = | 9911.0 | nM | 5.00 |
| CHEMBL595762 | 8-CYCLOHEXAMIDOMANZAMINE A | IC50 | = | 11140.0 | nM | 4.95 |
| CHEMBL595435 | 6-N-HEXAMIDOMANZAMINE A | IC50 | = | 15120.0 | nM | 4.82 |
| CHEMBL608122 | 6-N-OCTAMIDOMANZAMINE A | IC50 | = | 17400.0 | nM | 4.76 |