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Assay Detail

CHEMBL1046176

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]adenine from adenine 1 receptor in HEK293 cells by liquid scintillation counting
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type HEK293
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Structure-activity relationships of adenine and deazaadenine derivatives as ligands for adenine receptors, a new purinergic receptor family.
Borrmann T, Abdelrahman A, Volpini R, Lambertucci C, Alksnis E, Gorzalka S, Knospe M, Schiedel AC, Cristalli G, Müller CE.
J Med Chem (2009) 52 : 5974 -5989
PubMed 19731917 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 25 5.01 7.47

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL565451 1 7.47
CHEMBL226345 ADENINE 3.0 1 7.33
CHEMBL569454 1 6.29
CHEMBL577928 1 5.26
CHEMBL569487 1 5.21
CHEMBL33316 1 5.17
CHEMBL579385 1 5.10
CHEMBL393474 1 5.02
CHEMBL566793 1 4.91
CHEMBL394752 1 4.76
CHEMBL569925 1 4.73
CHEMBL566183 1 4.56
CHEMBL566182 1 4.50
CHEMBL566158 1 4.48
CHEMBL576076 1 4.47
CHEMBL454802 1 4.00
CHEMBL445696 1 4.00
CHEMBL571682 1 4.00
CHEMBL567755 1 4.00
CHEMBL569687 1 -
CHEMBL576077 1 -
CHEMBL576115 1 -
CHEMBL578818 1 -
CHEMBL449329 DEOXYADENOSINE 1 -
CHEMBL150192 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL565451 Ki = 34.1 nM 7.47
CHEMBL226345 ADENINE Ki = 47.1 nM 7.33
CHEMBL569454 Ki = 515.0 nM 6.29
CHEMBL577928 Ki = 5490.0 nM 5.26
CHEMBL569487 Ki = 6230.0 nM 5.21
CHEMBL33316 Ki = 6680.0 nM 5.17
CHEMBL579385 Ki = 7890.0 nM 5.10
CHEMBL393474 Ki = 9530.0 nM 5.02
CHEMBL566793 Ki = 12200.0 nM 4.91
CHEMBL394752 Ki = 17500.0 nM 4.76
CHEMBL569925 Ki = 18500.0 nM 4.73
CHEMBL566183 Ki = 27400.0 nM 4.56
CHEMBL566182 Ki = 31700.0 nM 4.50
CHEMBL566158 Ki = 32900.0 nM 4.48
CHEMBL576076 Ki = 34100.0 nM 4.47
CHEMBL454802 Ki = 100000.0 nM 4.00
CHEMBL445696 Ki = 100000.0 nM 4.00
CHEMBL571682 Ki = 100000.0 nM 4.00
CHEMBL567755 Ki = 100000.0 nM 4.00
CHEMBL569687 Ki > 100000.0 nM -
CHEMBL576077 Ki > 100000.0 nM -
CHEMBL576115 Ki > 100000.0 nM -
CHEMBL578818 Ki > 100000.0 nM -
CHEMBL449329 DEOXYADENOSINE Ki > 100000.0 nM -
CHEMBL150192 Ki = 110000.0 nM -