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Compound Detail

CHEMBL33316

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Nc1[nH]ccc2ncnc1-2

Basic Information

ChEMBL ID CHEMBL33316
Phase Preclinical
Structure Type MOL
InChI Key QIBLFAMJLVFXAT-UHFFFAOYSA-N
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
7
Publications
0
Known Names

Molecular Properties

134.1
MW (Da)
0.49
ALogP
3
HBA
2
HBD
67.6
PSA (Ų)
0.55
QED
0
Ro5 Violations
0
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C6H6N4
MW 134.14
Aromatic Rings 0
Heavy Atoms 10
NP-Likeness -0.87

Activity Summary

Ki 2 meas. best 5.17
IC50 1 meas. best 5.16

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
Ki 5.17 5.17 6680.0 2
HEp-2
CHEMBL614735
IC50 5.16 5.16 7000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
19731917 10.1021/jm9006356 Unchecked 3
2165159 10.1021/jm00170a005 Phosphatidylinositol 4-kinase, PI4K 1
6708054 10.1021/jm00370a018 HEp-2 1
3941408 10.1021/jm00151a022 Nucleic Acid 1
3941408 10.1021/jm00151a022 Mus musculus 1
3941408 10.1021/jm00151a022 EL4 1
3941408 10.1021/jm00151a022 Rattus norvegicus 1

Data from ChEMBL 36 via Core Engine