Assay Detail
Binding
CHEMBL1046285
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoazetidin-2-yl)phenoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid from human intestinal brush border membrane NPC1L1 by single tube filtration assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
NPC1-like intracellular cholesterol transporter 1 (CHEMBL2027) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Multiple strategies for the preparation of a sulfur-35 labeled NPC1L1 radioligand.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.61 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL578400 | — | — | 1 | 8.40 |
| CHEMBL578401 | — | — | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL578400 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL578401 | — | IC50 | = | 150.0 | nM | 6.82 |