Assay Detail
Functional
CHEMBL1046460
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Agonist activity at delta opioid receptor in mouse vas deferens assessed as inhibition of electrically-stimulated contraction
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Tissue | Vas deferens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The biological activity and metabolic stability of peptidic bifunctional compounds that are opioid receptor agonists and neurokinin-1 receptor antagonists with a cystine moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.67 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL200199 | BIPHALIN | — | 1 | 8.57 |
| CHEMBL611925 | — | — | 1 | 8.08 |
| CHEMBL592969 | — | — | 1 | 7.72 |
| CHEMBL595972 | — | — | 1 | 7.44 |
| CHEMBL611924 | — | — | 1 | 7.14 |
| CHEMBL611926 | — | — | 1 | 7.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL200199 | BIPHALIN | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL611925 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL592969 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL595972 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL611924 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL611926 | — | IC50 | = | 85.0 | nM | 7.07 |