Assay Detail
Binding
CHEMBL1046490
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Inhibition of calf thymus DNA polymerase alpha by [3H]dTTP incorporation assay
16
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of dehydroaltenusin derivatives as selective DNA polymerase alpha inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.64 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL594272 | — | — | 2 | 7.22 |
| CHEMBL595189 | — | — | 2 | 7.05 |
| CHEMBL594951 | — | — | 2 | 6.75 |
| CHEMBL594273 | — | — | 2 | 6.62 |
| CHEMBL594151 | DEHYDROALTENUSIN | — | 2 | 6.17 |
| CHEMBL611034 | DESMETHYLDEHYDROALTENUSIN | — | 2 | 6.05 |
| CHEMBL593327 | — | — | 1 | - |
| CHEMBL593328 | — | — | 1 | - |
| CHEMBL595213 | — | — | 1 | - |
| CHEMBL595214 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL594272 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL595189 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL594951 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL594273 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL594151 | DEHYDROALTENUSIN | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL611034 | DESMETHYLDEHYDROALTENUSIN | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL593327 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL593328 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL595213 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL595214 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL594151 | DEHYDROALTENUSIN | IC50 | - | — | - | |
| CHEMBL611034 | DESMETHYLDEHYDROALTENUSIN | IC50 | - | — | - | |
| CHEMBL594951 | — | IC50 | - | — | - | |
| CHEMBL595189 | — | IC50 | - | — | - | |
| CHEMBL594272 | — | IC50 | - | — | - | |
| CHEMBL594273 | — | IC50 | - | — | - |