Assay Detail
ADMET
CHEMBL1046517
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Growth inhibition of human WI38 cells after 72 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | WI-38 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Lycorine, the main phenanthridine Amaryllidaceae alkaloid, exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli: an investigation of structure-activity relationship and mechanistic insight.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.36 | 4.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL575109 | — | — | 1 | 4.54 |
| CHEMBL481250 | ANHYDROLYCORINE | — | 1 | 4.52 |
| CHEMBL586091 | PSEUDOLYCORINE | — | 1 | 4.36 |
| CHEMBL575771 | — | — | 1 | 4.34 |
| CHEMBL516707 | — | — | 1 | 4.05 |
| CHEMBL400092 | LYCORINE | — | 1 | - |
| CHEMBL574915 | LYCORINE HYDROCHLORIDE | — | 1 | - |
| CHEMBL575533 | AMARBELLISINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL575109 | — | IC50 | = | 28600.0 | nM | 4.54 |
| CHEMBL481250 | ANHYDROLYCORINE | IC50 | = | 30100.0 | nM | 4.52 |
| CHEMBL586091 | PSEUDOLYCORINE | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL575771 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL516707 | — | IC50 | = | 88500.0 | nM | 4.05 |
| CHEMBL400092 | LYCORINE | IC50 | > | 100000.0 | nM | - |
| CHEMBL574915 | LYCORINE HYDROCHLORIDE | IC50 | > | 100000.0 | nM | - |
| CHEMBL575533 | AMARBELLISINE | IC50 | > | 100000.0 | nM | - |