Assay Detail
Binding
CHEMBL1046597
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Inhibition of human recombinant cytosolic carbonic anhydrase 1 by stopped-flow CO2 hydration assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 7.05 | 7.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL750 | ZONISAMIDE | 4.0 | 1 | 7.25 |
| CHEMBL574779 | — | — | 1 | 7.22 |
| CHEMBL573859 | — | — | 1 | 7.22 |
| CHEMBL573127 | — | — | 1 | 7.21 |
| CHEMBL583971 | — | — | 1 | 7.21 |
| CHEMBL582841 | — | — | 1 | 7.20 |
| CHEMBL583171 | — | — | 1 | 7.17 |
| CHEMBL575660 | — | — | 1 | 7.17 |
| CHEMBL574245 | — | — | 1 | 7.15 |
| CHEMBL573381 | — | — | 1 | 7.14 |
| CHEMBL574780 | — | — | 1 | 7.14 |
| CHEMBL574783 | — | — | 1 | 7.12 |
| CHEMBL582965 | — | — | 1 | 7.12 |
| CHEMBL573335 | — | — | 1 | 7.11 |
| CHEMBL584387 | — | — | 1 | 7.08 |
| CHEMBL574782 | — | — | 1 | 6.97 |
| CHEMBL574246 | — | — | 1 | 6.79 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.60 |
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | 6.60 |
| CHEMBL574021 | — | — | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL750 | ZONISAMIDE | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL574779 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL573859 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL573127 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL583971 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL582841 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL583171 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL575660 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL574245 | — | Ki | = | 71.0 | nM | 7.15 |
| CHEMBL573381 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL574780 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL574783 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL582965 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL573335 | — | Ki | = | 77.0 | nM | 7.11 |
| CHEMBL584387 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL574782 | — | Ki | = | 108.0 | nM | 6.97 |
| CHEMBL574246 | — | Ki | = | 161.0 | nM | 6.79 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL220492 | TOPIRAMATE | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL574021 | — | Ki | = | 263.0 | nM | 6.58 |