Assay Detail
Binding
CHEMBL1046751
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Displacement of [3H]diprenorphine from rat mu opioid receptor expressed in rat C6 cells after 1 hr by liquid scintillation counting
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | C6 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Pentapeptides displaying mu opioid receptor agonist and delta opioid receptor partial agonist/antagonist properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 9.43 | 10.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL583066 | — | — | 1 | 10.80 |
| CHEMBL583067 | — | — | 1 | 10.10 |
| CHEMBL583274 | — | — | 1 | 9.48 |
| CHEMBL572525 | — | — | 1 | 9.33 |
| CHEMBL583275 | — | — | 1 | 9.33 |
| CHEMBL583277 | — | — | 1 | 9.21 |
| CHEMBL572524 | — | — | 1 | 9.14 |
| CHEMBL583278 | — | — | 1 | 8.92 |
| CHEMBL583276 | — | — | 1 | 8.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL583066 | — | Ki | = | 0.016 | nM | 10.80 |
| CHEMBL583067 | — | Ki | = | 0.08 | nM | 10.10 |
| CHEMBL583274 | — | Ki | = | 0.33 | nM | 9.48 |
| CHEMBL572525 | — | Ki | = | 0.47 | nM | 9.33 |
| CHEMBL583275 | — | Ki | = | 0.47 | nM | 9.33 |
| CHEMBL583277 | — | Ki | = | 0.61 | nM | 9.21 |
| CHEMBL572524 | — | Ki | = | 0.72 | nM | 9.14 |
| CHEMBL583278 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL583276 | — | Ki | = | 2.5 | nM | 8.60 |