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Assay Detail

CHEMBL1047006

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Binding
Inhibition of human PHD2 at 293K temperature by solvent relaxation technique
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Egl nine homolog 1 (CHEMBL5697)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Using NMR solvent water relaxation to investigate metalloenzyme-ligand binding interactions.
Leung IK, Flashman E, Yeoh KK, Schofield CJ, Claridge TD.
J Med Chem (2010) 53 : 867 -875
PubMed 20025281 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 9 5.98 7.68

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL570655 1 7.68
CHEMBL426560 1 7.14
CHEMBL485022 1 6.29
CHEMBL90852 N-OXALYLGLYCINE 1 4.73
CHEMBL576 SUCCINIC ACID 3.0 1 4.07
CHEMBL1686 ALPHA-KETOGLUTARIC ACID 1 -
CHEMBL568873 1 -
CHEMBL569062 1 -
CHEMBL485023 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL570655 IC50 = 21.0 nM 7.68
CHEMBL426560 IC50 = 73.0 nM 7.14
CHEMBL485022 IC50 = 512.0 nM 6.29
CHEMBL90852 N-OXALYLGLYCINE IC50 = 18500.0 nM 4.73
CHEMBL576 SUCCINIC ACID IC50 = 85300.0 nM 4.07
CHEMBL1686 ALPHA-KETOGLUTARIC ACID IC50 - -
CHEMBL568873 IC50 > 400000.0 nM -
CHEMBL569062 IC50 > 400000.0 nM -
CHEMBL485023 IC50 = 230000.0 nM -