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Compound Detail

CHEMBL576

SUCCINIC ACID
🧪 Phase III
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🧪 Phase III
O=C(O)CCC(=O)O
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL576
Name SUCCINIC ACID
Phase Phase III
Structure Type MOL
InChI Key KDYFGRWQOYBRFD-UHFFFAOYSA-N

Known Names

Amber acid Dihydrofumaric acid E363 FEMA NO. 4719 NSC-106449 Succinic acid Succinicum acidum
6
Targets
37
Activities
4
Assay Types
1
PK Parameters
20
Publications
7
Known Names
2
Indications

Molecular Properties

118.1
MW (Da)
-0.06
ALogP
2
HBA
2
HBD
74.6
PSA (Ų)
0.54
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Chirality Achiral

Flags

Natural Product

Extended Properties

Molecular Formula C4H6O4
MW 118.09
Aromatic Rings 0
Heavy Atoms 8
NP-Likeness 0.38

Indications

Diabetic Neuropathies Stroke

Activity Summary

IC50 22 meas. best 8.89
EC50 9 meas. best 5.69
Ki 5 meas.
Kd 1 meas.

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Vero
CHEMBL391
 IC50 8.89 8.89 1.3 1
Succinate receptor 1
CHEMBL4739861
 EC50 5.69 5.3333 2041.7 3
Egl nine homolog 1
CHEMBL5697
 IC50 5.52 4.795 3000.0 2
Succinate receptor 1
CHEMBL2150838
 EC50 5.04 4.7633 9120.1 3
Unchecked
CHEMBL612545
 IC50 4.83 4.45 14791.1 2
Unchecked
CHEMBL612545
 EC50 4.76 4.52 17378.0 2
RNA demethylase ALKBH5
CHEMBL3621037
 IC50 4.52 4.52 30000.0 1

Pharmacokinetic Data

Parameter Value Units Species
T1/2 2.0 hr Homo sapiens

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Vero IC50 = 1.3 nM 8.89 Anti-Herpes simplex virus type-1 activity in vero cells using plaque inhibition ... 10464017
Succinate receptor 1 EC50 = 2041.74 nM 5.69 Agonist activity at N-terminal Nluc-tagged mouse Succinate receptor 1 expressed ... 37318348
Egl nine homolog 1 IC50 = 3000.0 nM 5.52 Inhibition of 2-oxoglutarate-dependent human recombinant HIF PHD2 preincubated f... 18942826
Succinate receptor 1 EC50 = 5128.61 nM 5.29 Agonist activity at mouse succinate receptor 1 expressed in HEK293T cells co-tra... 37318348
Succinate receptor 1 EC50 = 9120.11 nM 5.04 Agonist activity at human succinate receptor 1 expressed in human Flp-In-T-REx-2... 37318348
Succinate receptor 1 EC50 = 9549.93 nM 5.02 Agonist activity at mouse succinate receptor 1 expressed in human Flp-In-T-REx-2... 37318348
Unchecked IC50 = 14791.08 nM 4.83 Inhibition of N-terminal His-tagged recombinant human TET2 catalytic domain LCId... 38294854
Succinate receptor 1 EC50 = 15848.93 nM 4.8 Agonist activity at N-terminal Nluc-tagged human Succinate receptor 1 expressed ... 37318348
Unchecked EC50 = 17378.01 nM 4.76 Agonist activity at mouse succinate receptor 1 N181.31E/K2697.32N mutant express... 37318348
RNA demethylase ALKBH5 IC50 = 30000.0 nM 4.52 Inhibition of recombinant human ALKBH5 catalytic AlkB domain (74 to 294 residues... 34792334
Succinate receptor 1 EC50 = 35481.34 nM 4.45 Agonist activity at human succinate receptor 1 expressed in HEK293T cells co-tra... 37318348
Unchecked EC50 = 52480.75 nM 4.28 Agonist activity at mouse succinate receptor 1 N181.31E/K2697.32N/G84EL1W mutant... 37318348
Unchecked IC50 = 85300.0 nM 4.07 Destabilizing effect on human recombinant PHD2 (181-426) expressed in Escherichi... 19364117
Egl nine homolog 1 IC50 = 85300.0 nM 4.07 Inhibition of human PHD2 at 293K temperature by solvent relaxation technique 20025281

Literature References

PubMed DOI Target Context # Activities
37318348 10.1021/acs.jmedchem.3c00552 Succinate receptor 1 11
37318348 10.1021/acs.jmedchem.3c00552 Unchecked 4
18942826 10.1021/jm800936s Unchecked 3
20025281 10.1021/jm901537q Egl nine homolog 1 3
19364117 10.1021/jm900285r Unchecked 2
- 10.6019/CHEMBL4495565 SARS-CoV-2 2
385880 10.1021/jm00195a019 Candida albicans 2
- 10.6019/CHEMBL4651402 SARS-CoV-2 2
23234607 10.1021/jm301583m Egl nine homolog 1 2
- 10.6019/CHEMBL4808148 Histone deacetylase 6 2
37468498 10.1038/s41467-023-40064-9 Alpha-1A adrenergic receptor 2
38294854 10.1021/acs.jmedchem.3c01820 Methylcytosine dioxygenase TET2 2
38294854 10.1021/acs.jmedchem.3c01820 Unchecked 2
37468498 10.1038/s41467-023-40064-9 Thromboxane A2 receptor 2
37468498 10.1038/s41467-023-40064-9 Prostaglandin G/H synthase 1 2
38294854 10.1021/acs.jmedchem.3c01820 Methylcytosine dioxygenase TET3 2
37468498 10.1038/s41467-023-40064-9 Muscarinic acetylcholine receptor M1 2
38294854 10.1021/acs.jmedchem.3c01820 Methylcytosine dioxygenase TET1 2
7328595 10.1021/jm00140a003 Mus musculus 2
36931124 10.1016/j.ejmech.2023.115250 Lysine-specific demethylase 5B 1

Data from ChEMBL 36 via Core Engine