RNA demethylase ALKBH5 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q6P6C2. Use UniProt Q6P6C2 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q6P6C2 as the stable identity anchor, then attach disease evidence before program review.
RNA demethylase ALKBH5
Review this target as RNA demethylase ALKBH5, mapped to UniProt Q6P6C2. Sequence length is 394 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats RNA demethylase ALKBH5 as ChEMBL target CHEMBL3621037, mapped to UniProt Q6P6C2. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | RNA demethylase ALKBH5 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q6P6C2 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | RNA demethylase ALKBH5 |
| UniProt Accession | Q6P6C2 |
| Component Type | Protein |
| Sequence Length | 394 aa |
RNA demethylase ALKBH5
Review this target as RNA demethylase ALKBH5, mapped to UniProt Q6P6C2. Sequence length is 394 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5203605 | 7.68 | IC50 | 21.0 | Preclinical |
| CHEMBL5172537 | 7.21 | IC50 | 61.0 | Preclinical |
| CHEMBL25336 | 6.85 | IC50 | 140.0 | Clinical |
| CHEMBL5205465 | 6.4 | IC50 | 396.0 | Preclinical |
| CHEMBL5175898 | 6.38 | IC50 | 421.0 | Preclinical |
| CHEMBL5186162 | 6.25 | IC50 | 559.0 | Preclinical |
| CHEMBL5208142 | 6.23 | IC50 | 591.0 | Preclinical |
| CHEMBL38434 | 6.15 | IC50 | 710.0 | Clinical |
| CHEMBL5180828 | 6.14 | IC50 | 727.0 | Preclinical |
| CHEMBL4752151 | 6.08 | IC50 | 840.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 24 | 30 | 5.6 |
| assay format | 22 | 22 | 4.9 |
| single protein format | 17 | 30 | 5.2 |