Compound Detail
CHEMBL5205465
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5205465 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CKVCPTUGCUSCNU-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
286.2
MW (Da)
2.60
ALogP
4
HBA
2
HBD
75.3
PSA (Ų)
0.89
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| RNA demethylase ALKBH5 CHEMBL3621037 | IC50 | 6.4 | 6.4 | 396.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| RNA demethylase ALKBH5 | IC50 | = | 396.0 | nM | 6.4 | Inhibition of human recombinant ALKBH5 (66 to 292 residues) expressed in Escheri... | 35597008 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35597008 | 10.1016/j.ejmech.2022.114446 | RNA demethylase ALKBH5 | 1 |
Data from ChEMBL 36 via Core Engine