Assay Detail
Binding
CHEMBL946281
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 2-oxoglutarate-dependent human recombinant HIF PHD2 preincubated for 1 hr
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.12 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL576 | SUCCINIC ACID | 3.0 | 1 | 5.52 |
| CHEMBL503160 | FUMARIC ACID | 3.0 | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL576 | SUCCINIC ACID | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL503160 | FUMARIC ACID | IC50 | = | 19000.0 | nM | 4.72 |