Assay Detail
Functional
CHEMBL1047018
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Growth inhibition of human Tcf 33.13 cells transiently transfected with pGL3-Tcf4-luc and SV40-R-luc after 3 days by luminescent cell viability assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of novel diaminoquinazolines with in vivo efficacy for beta-catenin/T-cell transcriptional factor 4 pathway inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.32 | 6.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL569919 | — | — | 1 | 6.42 |
| CHEMBL568799 | — | — | 1 | 6.35 |
| CHEMBL569103 | — | — | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL569919 | — | IC50 | = | 385.0 | nM | 6.42 |
| CHEMBL568799 | — | IC50 | = | 447.0 | nM | 6.35 |
| CHEMBL569103 | — | IC50 | = | 648.0 | nM | 6.19 |