Assay Detail
Functional
CHEMBL1047076
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Might adrenergic alpha2C-agonists/alpha2A-antagonists become novel therapeutic tools for pain treatment with morphine?
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.94 | 7.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL569933 | — | — | 1 | 7.21 |
| CHEMBL570973 | — | — | 1 | 6.00 |
| CHEMBL576623 | — | — | 1 | 6.00 |
| CHEMBL13852 | CIRAZOLINE | 2.0 | 1 | 6.00 |
| CHEMBL576819 | — | — | 1 | 5.60 |
| CHEMBL576078 | — | — | 1 | 5.50 |
| CHEMBL570863 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL569933 | — | EC50 | = | 61.66 | nM | 7.21 |
| CHEMBL570973 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL576623 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL13852 | CIRAZOLINE | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL576819 | — | EC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL576078 | — | EC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL570863 | — | EC50 | = | 5011.87 | nM | 5.30 |