Assay Detail
Binding
CHEMBL1047422
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Inhibition of Tie2
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Selective inhibitors of the mutant B-Raf pathway: discovery of a potent and orally bioavailable aminoisoquinoline.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.48 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL212964 | — | — | 1 | 8.74 |
| CHEMBL385956 | — | — | 1 | 8.44 |
| CHEMBL570573 | — | — | 1 | 8.24 |
| CHEMBL571278 | — | — | 1 | 8.09 |
| CHEMBL565885 | — | — | 1 | 7.62 |
| CHEMBL571703 | — | — | 1 | 7.33 |
| CHEMBL3215582 | — | — | 1 | 6.92 |
| CHEMBL569882 | — | — | 1 | 6.70 |
| CHEMBL570567 | — | — | 1 | 6.40 |
| CHEMBL565884 | — | — | 1 | 6.28 |
| CHEMBL576985 | — | — | 1 | - |
| CHEMBL576787 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL212964 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL385956 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL570573 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL571278 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL565885 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL571703 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL3215582 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL569882 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL570567 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL565884 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL576985 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL576787 | — | IC50 | > | 1000.0 | nM | - |