Assay Detail
Functional
CHEMBL1047696
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 3B in human MT2 cells assessed as inhibition of cell-cell fusion
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Structure-based design, synthesis and biological evaluation of new N-carboxyphenylpyrrole derivatives as HIV fusion inhibitors targeting gp41.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.66 | 5.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL610200 | — | — | 1 | 5.44 |
| CHEMBL595044 | — | — | 1 | 5.08 |
| CHEMBL610199 | — | — | 1 | 4.58 |
| CHEMBL214344 | — | — | 1 | 4.36 |
| CHEMBL610733 | — | — | 1 | 4.29 |
| CHEMBL595968 | — | — | 1 | 4.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL610200 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL595044 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL610199 | — | IC50 | = | 26010.0 | nM | 4.58 |
| CHEMBL214344 | — | IC50 | = | 43240.0 | nM | 4.36 |
| CHEMBL610733 | — | IC50 | = | 51610.0 | nM | 4.29 |
| CHEMBL595968 | — | IC50 | = | 59170.0 | nM | 4.23 |