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Assay Detail

CHEMBL1047697

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]T0901317 from human recombinant LXRalpha-LBD
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Oxysterols receptor LXR-alpha (CHEMBL2808)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

4-(3-Aryloxyaryl)quinoline sulfones are potent liver X receptor agonists.
Bernotas RC, Singhaus RR, Kaufman DH, Travins JM, Ullrich JW, Unwalla R, Quinet E, Evans M, Nambi P, Olland A, Kauppi B, Wilhelmsson A, Goos-Nilsson A, Wrobel J.
Bioorg Med Chem Lett (2010) 20 : 209 -212
PubMed 19932617 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 23 8.36 9.04

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL592506 1 9.04
CHEMBL595689 1 9.00
CHEMBL595782 1 8.96
CHEMBL606539 1 8.92
CHEMBL593472 1 8.85
CHEMBL593473 1 8.80
CHEMBL595113 1 8.74
CHEMBL594175 1 8.72
CHEMBL595344 1 8.62
CHEMBL595580 1 8.59
CHEMBL593241 1 8.55
CHEMBL594176 1 8.52
CHEMBL595118 1 8.52
CHEMBL595804 1 8.49
CHEMBL593471 1 8.14
CHEMBL595345 1 8.09
CHEMBL604582 1 8.09
CHEMBL607090 1 8.09
CHEMBL461890 1 8.05
CHEMBL62136 T091317 1 8.05
CHEMBL594174 1 7.89
CHEMBL593884 1 7.38
CHEMBL595045 1 6.25

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL592506 IC50 = 0.92 nM 9.04
CHEMBL595689 IC50 = 1.0 nM 9.00
CHEMBL595782 IC50 = 1.1 nM 8.96
CHEMBL606539 IC50 = 1.2 nM 8.92
CHEMBL593472 IC50 = 1.4 nM 8.85
CHEMBL593473 IC50 = 1.6 nM 8.80
CHEMBL595113 IC50 = 1.8 nM 8.74
CHEMBL594175 IC50 = 1.9 nM 8.72
CHEMBL595344 IC50 = 2.4 nM 8.62
CHEMBL595580 IC50 = 2.6 nM 8.59
CHEMBL593241 IC50 = 2.8 nM 8.55
CHEMBL594176 IC50 = 3.0 nM 8.52
CHEMBL595118 IC50 = 3.0 nM 8.52
CHEMBL595804 IC50 = 3.2 nM 8.49
CHEMBL593471 IC50 = 7.2 nM 8.14
CHEMBL595345 IC50 = 8.1 nM 8.09
CHEMBL604582 IC50 = 8.2 nM 8.09
CHEMBL607090 IC50 = 8.2 nM 8.09
CHEMBL461890 IC50 = 9.0 nM 8.05
CHEMBL62136 T091317 IC50 = 9.0 nM 8.05
CHEMBL594174 IC50 = 13.0 nM 7.89
CHEMBL593884 IC50 = 42.0 nM 7.38
CHEMBL595045 IC50 = 560.0 nM 6.25