Compound Detail
CHEMBL604582
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Cc1cnc2c(C(F)(F)F)cccc2c1-c1cccc(Oc2cccc(S(=O)(=O)CCC(C)(C)O)c2)c1
Basic Information
| ChEMBL ID | CHEMBL604582 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UCPCLSOVORSWOU-UHFFFAOYSA-N |
4
Targets
4
Activities
2
Assay Types
1
PK Parameters
6
Publications
0
Known Names
Molecular Properties
529.6
MW (Da)
6.96
ALogP
5
HBA
1
HBD
76.5
PSA (Ų)
0.28
QED
2
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 6.2
IC50 2 meas. best 8.09
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Oxysterols receptor LXR-alpha CHEMBL2808 | IC50 | 8.09 | 8.09 | 8.2 | 1 |
| Oxysterols receptor LXR-beta CHEMBL4093 | IC50 | 6.92 | 6.92 | 121.0 | 1 |
| J774.A1 CHEMBL614040 | EC50 | 6.2 | 6.2 | 636.0 | 1 |
| Liver X receptor CHEMBL3706564 | EC50 | 6.02 | 6.02 | 962.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| T1/2 | 0.5 | hr | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Oxysterols receptor LXR-alpha | IC50 | = | 8.2 | nM | 8.09 | Displacement of [3H]T0901317 from human recombinant LXRalpha-LBD | 19932617 |
| Oxysterols receptor LXR-beta | IC50 | = | 121.0 | nM | 6.92 | Displacement of [3H]T0901317 from human recombinant LXRbeta-LBD | 19932617 |
| J774.A1 | EC50 | = | 636.0 | nM | 6.2 | Induction of ABCA1 mRNA expression in mouse J774A1 cells | 19932617 |
| Liver X receptor | EC50 | = | 962.0 | nM | 6.02 | Agonist activity at human recombinant LXR-LBD by Gal4beta transactivation assay | 19932617 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19932617 | 10.1016/j.bmcl.2009.10.132 | J774.A1 | 2 |
| 19932617 | 10.1016/j.bmcl.2009.10.132 | Liver X receptor | 2 |
| 19932617 | 10.1016/j.bmcl.2009.10.132 | Liver microsomes | 1 |
| 19932617 | 10.1016/j.bmcl.2009.10.132 | Oxysterols receptor LXR-beta | 1 |
| 19932617 | 10.1016/j.bmcl.2009.10.132 | Oxysterols receptor LXR-alpha | 1 |
| 19932617 | 10.1016/j.bmcl.2009.10.132 | Liver X receptor (LXR alpha AND LXR beta) | 1 |
Data from ChEMBL 36 via Core Engine