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Assay Detail

CHEMBL1047702

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Induction of ABCA1 mRNA expression in mouse J774A1 cells
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type J774.A1
Confidence 1 — Organism
Curated By Autocuration

Target

J774.A1 (CHEMBL614040)
Type CELL-LINE
Organism Mus musculus

Publication

4-(3-Aryloxyaryl)quinoline sulfones are potent liver X receptor agonists.
Bernotas RC, Singhaus RR, Kaufman DH, Travins JM, Ullrich JW, Unwalla R, Quinet E, Evans M, Nambi P, Olland A, Kauppi B, Wilhelmsson A, Goos-Nilsson A, Wrobel J.
Bioorg Med Chem Lett (2010) 20 : 209 -212
PubMed 19932617 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 23 7.33 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL595113 1 8.52
CHEMBL593473 1 8.52
CHEMBL592506 1 8.30
CHEMBL595689 1 8.22
CHEMBL595580 1 8.00
CHEMBL594175 1 7.85
CHEMBL595344 1 7.66
CHEMBL593472 1 7.62
CHEMBL62136 T091317 1 7.46
CHEMBL595345 1 7.26
CHEMBL593241 1 7.16
CHEMBL593471 1 7.09
CHEMBL594174 1 6.81
CHEMBL594176 1 6.79
CHEMBL607090 1 6.59
CHEMBL461890 1 6.56
CHEMBL593884 1 6.34
CHEMBL595118 1 6.26
CHEMBL604582 1 6.20
CHEMBL595804 1 -
CHEMBL595782 1 -
CHEMBL606539 1 -
CHEMBL595045 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL595113 EC50 = 3.0 nM 8.52
CHEMBL593473 EC50 = 3.0 nM 8.52
CHEMBL592506 EC50 = 5.0 nM 8.30
CHEMBL595689 EC50 = 6.0 nM 8.22
CHEMBL595580 EC50 = 10.0 nM 8.00
CHEMBL594175 EC50 = 14.0 nM 7.85
CHEMBL595344 EC50 = 22.0 nM 7.66
CHEMBL593472 EC50 = 24.0 nM 7.62
CHEMBL62136 T091317 EC50 = 35.0 nM 7.46
CHEMBL595345 EC50 = 55.0 nM 7.26
CHEMBL593241 EC50 = 70.0 nM 7.16
CHEMBL593471 EC50 = 81.0 nM 7.09
CHEMBL594174 EC50 = 154.0 nM 6.81
CHEMBL594176 EC50 = 162.0 nM 6.79
CHEMBL607090 EC50 = 256.0 nM 6.59
CHEMBL461890 EC50 = 276.0 nM 6.56
CHEMBL593884 EC50 = 453.0 nM 6.34
CHEMBL595118 EC50 = 555.0 nM 6.26
CHEMBL604582 EC50 = 636.0 nM 6.20
CHEMBL595804 EC50 - -
CHEMBL595782 EC50 - -
CHEMBL606539 EC50 - -
CHEMBL595045 EC50 - -