Assay Detail
Binding
CHEMBL1047738
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of alpha6beta2 nAChR
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor; alpha6/beta2 (CHEMBL2109237) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Structural basis for alpha-conotoxin potency and selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.84 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL594330 | — | — | 1 | 9.80 |
| CHEMBL595286 | — | — | 1 | 9.59 |
| CHEMBL595311 | — | — | 1 | 9.41 |
| CHEMBL595047 | — | — | 1 | 9.02 |
| CHEMBL609593 | — | — | 1 | 8.52 |
| CHEMBL609594 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL594330 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL595286 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL595311 | — | IC50 | = | 0.39 | nM | 9.41 |
| CHEMBL595047 | — | IC50 | = | 0.95 | nM | 9.02 |
| CHEMBL609593 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL609594 | — | IC50 | = | 201.0 | nM | 6.70 |