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Compound Detail

CHEMBL595286

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CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CS)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CS)NC(=O)[C@H](CS)NC(=O)CN)[C@@H](C)O)C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CS)C(=O)O

Basic Information

ChEMBL ID CHEMBL595286
Phase Preclinical
Structure Type BOTH
InChI Key WHDFCXQEDDAKHI-OKLNXYDLSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

1316.6
MW (Da)

Drug Information

Molecule Type Protein
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C54H85N13O17S4
MW 1316.62

Activity Summary

IC50 2 meas. best 9.59

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Neuronal acetylcholine receptor; alpha6/beta2
CHEMBL2109237
IC50 9.59 9.59 0.3 1
Neuronal acetylcholine receptor; alpha3/beta2
CHEMBL2109234
IC50 8.24 8.24 5.7 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
19628399 10.1016/j.bmc.2009.07.005 Unchecked 2
19628399 10.1016/j.bmc.2009.07.005 Neuronal acetylcholine receptor; alpha6/beta2 1
19628399 10.1016/j.bmc.2009.07.005 Neuronal acetylcholine receptor; alpha3/beta2 1

Data from ChEMBL 36 via Core Engine