Assay Detail
Binding
CHEMBL1047966
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Inhibition of recombinant vaccina H1-related phosphatase
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Dual specificity protein phosphatase 3 (CHEMBL2635) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Multidentate small-molecule inhibitors of vaccinia H1-related (VHR) phosphatase decrease proliferation of cervix cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.48 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL565795 | — | — | 1 | 7.75 |
| CHEMBL567069 | — | — | 1 | 7.15 |
| CHEMBL584481 | — | — | 1 | 7.13 |
| CHEMBL565810 | — | — | 1 | 7.11 |
| CHEMBL565371 | — | — | 1 | 6.57 |
| CHEMBL567473 | — | — | 1 | 5.75 |
| CHEMBL585093 | — | — | 1 | 5.75 |
| CHEMBL584887 | — | — | 1 | 5.62 |
| CHEMBL565584 | — | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL565795 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL567069 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL584481 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL565810 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL565371 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL567473 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL585093 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL584887 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL565584 | — | IC50 | = | 3100.0 | nM | 5.51 |