Dual specificity protein phosphatase 3 · SINGLE PROTEIN · Homo sapiens
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Protein identity stays anchored to UniProt P51452. Use UniProt P51452 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P51452 as the stable identity anchor, then attach disease evidence before program review.
Dual specificity protein phosphatase 3
Review this target as Dual specificity protein phosphatase 3, mapped to UniProt P51452. Sequence length is 185 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Dual specificity protein phosphatase 3 as ChEMBL target CHEMBL2635, mapped to UniProt P51452. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Dual specificity protein phosphatase 3 is the right protein anchor across sources, using UniProt P51452 as the stable mapping.
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| Preferred Name | Dual specificity protein phosphatase 3 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P51452 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Dual specificity protein phosphatase 3 |
| UniProt Accession | P51452 |
| Component Type | Protein |
| Sequence Length | 185 aa |
Dual specificity protein phosphatase 3
Review this target as Dual specificity protein phosphatase 3, mapped to UniProt P51452. Sequence length is 185 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL565795 | 7.75 | IC50 | 18.0 | Preclinical |
| CHEMBL1460470 | 7.19 | IC50 | 65.0 | Preclinical |
| CHEMBL567069 | 7.15 | IC50 | 71.0 | Preclinical |
| CHEMBL584481 | 7.13 | IC50 | 74.0 | Preclinical |
| CHEMBL565810 | 7.11 | IC50 | 78.0 | Preclinical |
| CHEMBL1608642 | 6.9 | IC50 | 127.0 | Preclinical |
| CHEMBL1322542 | 6.84 | IC50 | 143.0 | Preclinical |
| CHEMBL1463248 | 6.79 | IC50 | 163.0 | Preclinical |
| CHEMBL1448629 | 6.74 | IC50 | 181.0 | Preclinical |
| CHEMBL1385949 | 6.67 | IC50 | 216.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 77 | 284 | 5.2 |
| assay format | 14 | 47 | 5.2 |
| cell-based format | 3 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 5 | 261 | 5.4 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 0 | — |