Compound Detail
CHEMBL1460470
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Basic Information
| ChEMBL ID | CHEMBL1460470 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LCOYYIYBAKWSIQ-UHFFFAOYSA-N |
15
Targets
17
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
382.9
MW (Da)
2.95
ALogP
4
HBA
2
HBD
89.3
PSA (Ų)
0.85
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 12 meas. best 7.19
EC50 5 meas. best 4.87
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Dual specificity protein phosphatase 3 CHEMBL2635 | IC50 | 7.19 | 7.0633 | 65.0 | 3 |
| Tyrosine-protein phosphatase non-receptor type 7 CHEMBL2219 | IC50 | 7.18 | 7.18 | 66.0 | 1 |
| 26S proteasome non-ATPase regulatory subunit 14 CHEMBL2007629 | IC50 | 6.12 | 6.12 | 763.0 | 1 |
| 72 kDa type IV collagenase CHEMBL333 | IC50 | 5.57 | 5.57 | 2680.0 | 1 |
| Dual specificity protein phosphatase 6 CHEMBL5511 | IC50 | 5.53 | 5.53 | 2965.0 | 1 |
| Likely tRNA 2'-phosphotransferase CHEMBL1293308 | IC50 | 5.36 | 5.36 | 4402.0 | 1 |
| Cysteine protease ATG4B CHEMBL1741221 | IC50 | 5.18 | 5.18 | 6640.0 | 1 |
| Envelope glycoprotein gp160 CHEMBL1293311 | IC50 | 5.08 | 5.08 | 8220.0 | 1 |
| RNA-binding protein pos-1 CHEMBL1293304 | EC50 | 4.87 | 4.87 | 13436.0 | 1 |
| Zinc finger protein mex-5 CHEMBL1293319 | EC50 | 4.72 | 4.72 | 18903.0 | 1 |
| Phospholipase A2 CHEMBL4426 | IC50 | 4.62 | 4.62 | 24100.0 | 1 |
| Prothrombin CHEMBL4471 | IC50 | 4.61 | 4.61 | 24500.0 | 1 |
| Intestinal-type alkaline phosphatase CHEMBL5573 | EC50 | 4.31 | 4.31 | 49400.0 | 1 |
| Alkaline phosphatase, germ cell type CHEMBL3402 | EC50 | 4.19 | 4.19 | 63900.0 | 1 |
| Alkaline phosphatase, tissue-nonspecific isozyme CHEMBL5979 | EC50 | 4.17 | 4.17 | 68100.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Data from ChEMBL 36 via Core Engine