Assay Detail
Functional
CHEMBL1964000
Review assay metadata, readout intent, target linkage, and publication context from the same page.
PUBCHEM_BIOASSAY: Dose Response validation of uHTS RPN11 inhibitor hits using a MMP-2 Fluorescence assay. (Class of assay: confirmatory)
396
Total Activities
396
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Category | confirmatory |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
PubChem BioAssay data set
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 396 | 4.84 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1402117 | — | — | 1 | 7.77 |
| CHEMBL1980844 | — | — | 1 | 7.12 |
| CHEMBL1994463 | — | — | 1 | 6.91 |
| CHEMBL1493011 | — | — | 1 | 6.52 |
| CHEMBL1445488 | — | — | 1 | 6.09 |
| CHEMBL1575767 | — | — | 1 | 6.02 |
| CHEMBL1503793 | — | — | 1 | 6.01 |
| CHEMBL1536896 | — | — | 1 | 5.98 |
| CHEMBL1403497 | — | — | 1 | 5.98 |
| CHEMBL1566994 | — | — | 1 | 5.67 |
| CHEMBL1556531 | — | — | 1 | 5.63 |
| CHEMBL1460470 | — | — | 1 | 5.57 |
| CHEMBL1546767 | — | — | 1 | 5.49 |
| CHEMBL1429479 | — | — | 1 | 5.46 |
| CHEMBL1393151 | — | — | 1 | 5.43 |
| CHEMBL1971033 | — | — | 1 | 5.42 |
| CHEMBL1348946 | — | — | 1 | 5.41 |
| CHEMBL1883011 | — | — | 1 | 5.37 |
| CHEMBL1381264 | — | — | 1 | 5.35 |
| CHEMBL1983001 | — | — | 1 | 5.35 |
| CHEMBL1898074 | — | — | 1 | 5.27 |
| CHEMBL1505300 | — | — | 1 | 5.24 |
| CHEMBL1369893 | — | — | 1 | 5.23 |
| CHEMBL1542128 | — | — | 1 | 5.20 |
| CHEMBL1492565 | — | — | 1 | 5.20 |
| CHEMBL1447158 | — | — | 1 | 5.09 |
| CHEMBL1985696 | — | — | 1 | 5.09 |
| CHEMBL1464805 | — | — | 1 | 5.08 |
| CHEMBL1501743 | — | — | 1 | 5.04 |
| CHEMBL1422807 | — | — | 1 | 5.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1402117 | — | IC50 | = | 16.9 | nM | 7.77 |
| CHEMBL1980844 | — | IC50 | = | 76.4 | nM | 7.12 |
| CHEMBL1994463 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL1493011 | — | IC50 | = | 302.0 | nM | 6.52 |
| CHEMBL1445488 | — | IC50 | = | 821.0 | nM | 6.09 |
| CHEMBL1575767 | — | IC50 | = | 947.0 | nM | 6.02 |
| CHEMBL1503793 | — | IC50 | = | 968.0 | nM | 6.01 |
| CHEMBL1536896 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL1403497 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL1566994 | — | IC50 | = | 2150.0 | nM | 5.67 |
| CHEMBL1556531 | — | IC50 | = | 2320.0 | nM | 5.63 |
| CHEMBL1460470 | — | IC50 | = | 2680.0 | nM | 5.57 |
| CHEMBL1546767 | — | IC50 | = | 3260.0 | nM | 5.49 |
| CHEMBL1429479 | — | IC50 | = | 3450.0 | nM | 5.46 |
| CHEMBL1393151 | — | IC50 | = | 3680.0 | nM | 5.43 |
| CHEMBL1971033 | — | IC50 | = | 3790.0 | nM | 5.42 |
| CHEMBL1348946 | — | IC50 | = | 3940.0 | nM | 5.41 |
| CHEMBL1883011 | — | IC50 | = | 4320.0 | nM | 5.37 |
| CHEMBL1983001 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL1381264 | — | IC50 | = | 4490.0 | nM | 5.35 |
| CHEMBL1898074 | — | IC50 | = | 5410.0 | nM | 5.27 |
| CHEMBL1505300 | — | IC50 | = | 5790.0 | nM | 5.24 |
| CHEMBL1369893 | — | IC50 | = | 5910.0 | nM | 5.23 |
| CHEMBL1542128 | — | IC50 | = | 6340.0 | nM | 5.20 |
| CHEMBL1492565 | — | IC50 | = | 6290.0 | nM | 5.20 |
| CHEMBL1985696 | — | IC50 | = | 8150.0 | nM | 5.09 |
| CHEMBL1447158 | — | IC50 | = | 8140.0 | nM | 5.09 |
| CHEMBL1464805 | — | IC50 | = | 8370.0 | nM | 5.08 |
| CHEMBL1501743 | — | IC50 | = | 9070.0 | nM | 5.04 |
| CHEMBL1422807 | — | IC50 | = | 9310.0 | nM | 5.03 |
| CHEMBL1410895 | — | IC50 | = | 9510.0 | nM | 5.02 |
| CHEMBL1982195 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL224857 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL1981538 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL1309895 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL1976677 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL1461270 | — | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL1411673 | — | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL1378952 | — | IC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL1427330 | — | IC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL1586269 | — | IC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL1434555 | — | IC50 | = | 18400.0 | nM | 4.74 |
| CHEMBL1325818 | — | IC50 | = | 18800.0 | nM | 4.73 |
| CHEMBL1452939 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL1564638 | — | IC50 | = | 20400.0 | nM | 4.69 |
| CHEMBL1538250 | — | IC50 | = | 20600.0 | nM | 4.69 |
| CHEMBL1428997 | — | IC50 | = | 21200.0 | nM | 4.67 |
| CHEMBL1548574 | — | IC50 | = | 21200.0 | nM | 4.67 |
| CHEMBL1501577 | — | IC50 | = | 22500.0 | nM | 4.65 |
| CHEMBL1362445 | — | IC50 | = | 23000.0 | nM | 4.64 |