Assay Detail
Functional
CHEMBL1963965
Review assay metadata, readout intent, target linkage, and publication context from the same page.
PUBCHEM_BIOASSAY: Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay. (Class of assay: confirmatory)
396
Total Activities
396
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Category | confirmatory |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
26S proteasome non-ATPase regulatory subunit 14 (CHEMBL2007629) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
PubChem BioAssay data set
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 396 | 4.71 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1610433 | — | — | 1 | 7.05 |
| CHEMBL1986889 | — | — | 1 | 6.18 |
| CHEMBL1471965 | — | — | 1 | 6.15 |
| CHEMBL1460470 | — | — | 1 | 6.12 |
| CHEMBL56542 | — | — | 1 | 6.10 |
| CHEMBL1347547 | — | — | 1 | 6.04 |
| CHEMBL1980844 | — | — | 1 | 5.98 |
| CHEMBL56731 | — | — | 1 | 5.89 |
| CHEMBL1994463 | — | — | 1 | 5.88 |
| CHEMBL1979539 | — | — | 1 | 5.85 |
| CHEMBL1984584 | — | — | 1 | 5.75 |
| CHEMBL1991303 | — | — | 1 | 5.74 |
| CHEMBL1333181 | — | — | 1 | 5.66 |
| CHEMBL1491016 | — | — | 1 | 5.63 |
| CHEMBL1706207 | — | — | 1 | 5.53 |
| CHEMBL1313324 | — | — | 1 | 5.53 |
| CHEMBL1974063 | — | — | 1 | 5.48 |
| CHEMBL1406738 | — | — | 1 | 5.48 |
| CHEMBL1302696 | — | — | 1 | 5.42 |
| CHEMBL1425576 | — | — | 1 | 5.38 |
| CHEMBL1548928 | — | — | 1 | 5.36 |
| CHEMBL1452158 | — | — | 1 | 5.33 |
| CHEMBL1587502 | — | — | 1 | 5.32 |
| CHEMBL1422472 | — | — | 1 | 5.31 |
| CHEMBL2003445 | — | — | 1 | 5.29 |
| CHEMBL442449 | — | — | 1 | 5.28 |
| CHEMBL1492305 | — | — | 1 | 5.28 |
| CHEMBL1992308 | — | — | 1 | 5.27 |
| CHEMBL1492565 | — | — | 1 | 5.24 |
| CHEMBL1421745 | — | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1610433 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL1986889 | — | IC50 | = | 658.0 | nM | 6.18 |
| CHEMBL1471965 | — | IC50 | = | 703.0 | nM | 6.15 |
| CHEMBL1460470 | — | IC50 | = | 763.0 | nM | 6.12 |
| CHEMBL56542 | — | IC50 | = | 798.0 | nM | 6.10 |
| CHEMBL1347547 | — | IC50 | = | 914.0 | nM | 6.04 |
| CHEMBL1980844 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL56731 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1994463 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL1979539 | — | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL1984584 | — | IC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL1991303 | — | IC50 | = | 1820.0 | nM | 5.74 |
| CHEMBL1333181 | — | IC50 | = | 2180.0 | nM | 5.66 |
| CHEMBL1491016 | — | IC50 | = | 2360.0 | nM | 5.63 |
| CHEMBL1706207 | — | IC50 | = | 2940.0 | nM | 5.53 |
| CHEMBL1313324 | — | IC50 | = | 2930.0 | nM | 5.53 |
| CHEMBL1974063 | — | IC50 | = | 3280.0 | nM | 5.48 |
| CHEMBL1406738 | — | IC50 | = | 3310.0 | nM | 5.48 |
| CHEMBL1302696 | — | IC50 | = | 3790.0 | nM | 5.42 |
| CHEMBL1425576 | — | IC50 | = | 4180.0 | nM | 5.38 |
| CHEMBL1548928 | — | IC50 | = | 4350.0 | nM | 5.36 |
| CHEMBL1452158 | — | IC50 | = | 4690.0 | nM | 5.33 |
| CHEMBL1587502 | — | IC50 | = | 4760.0 | nM | 5.32 |
| CHEMBL1422472 | — | IC50 | = | 4930.0 | nM | 5.31 |
| CHEMBL2003445 | — | IC50 | = | 5140.0 | nM | 5.29 |
| CHEMBL1492305 | — | IC50 | = | 5260.0 | nM | 5.28 |
| CHEMBL442449 | — | IC50 | = | 5310.0 | nM | 5.28 |
| CHEMBL1992308 | — | IC50 | = | 5420.0 | nM | 5.27 |
| CHEMBL1492565 | — | IC50 | = | 5820.0 | nM | 5.24 |
| CHEMBL1421745 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL1990774 | — | IC50 | = | 6460.0 | nM | 5.19 |
| CHEMBL1486214 | — | IC50 | = | 6650.0 | nM | 5.18 |
| CHEMBL1511181 | — | IC50 | = | 6710.0 | nM | 5.17 |
| CHEMBL1445488 | — | IC50 | = | 6790.0 | nM | 5.17 |
| CHEMBL1429479 | — | IC50 | = | 6760.0 | nM | 5.17 |
| CHEMBL1590386 | — | IC50 | = | 6850.0 | nM | 5.16 |
| CHEMBL2000877 | — | IC50 | = | 6880.0 | nM | 5.16 |
| CHEMBL1434377 | — | IC50 | = | 7120.0 | nM | 5.15 |
| CHEMBL1498705 | — | IC50 | = | 7280.0 | nM | 5.14 |
| CHEMBL1548574 | — | IC50 | = | 7210.0 | nM | 5.14 |
| CHEMBL1575767 | — | IC50 | = | 7330.0 | nM | 5.13 |
| CHEMBL1558644 | — | IC50 | = | 7640.0 | nM | 5.12 |
| CHEMBL1501743 | — | IC50 | = | 7840.0 | nM | 5.11 |
| CHEMBL224857 | — | IC50 | = | 7920.0 | nM | 5.10 |
| CHEMBL1460896 | — | IC50 | = | 8120.0 | nM | 5.09 |
| CHEMBL1305574 | — | IC50 | = | 8150.0 | nM | 5.09 |
| CHEMBL1536896 | — | IC50 | = | 8130.0 | nM | 5.09 |
| CHEMBL1458593 | — | IC50 | = | 8230.0 | nM | 5.08 |
| CHEMBL1888496 | — | IC50 | = | 8480.0 | nM | 5.07 |
| CHEMBL1982202 | — | IC50 | = | 8540.0 | nM | 5.07 |